The Innovation as a Discipline (IaaD) program accelerates commercialization for CTSI investigators through hands-on leadership of innovation-focused translational work. We offer comprehensive mentorship and project management, with a focus on projects spawned by IaaD activities (e.g., PInCh, AIP), CTSI Functions and Innovation Design Challenge programs. The CTSI Innovation Portfolio includes projects initiated through these new programs. The IaaD program includes Innovators-in-Residence, Innovation Facilitators, and an Innovation Project Manager who works with projects in our innovation portfolio to ensure they are properly designed from the initial concept to right-sized commercialization goals. We designed our approaches based on our experience in managing the PInCh and AIP projects in our CTSI Innovation Portfolio.